Research areas
Life extension research.
Connected disciplines.
Explore the ideas shaping longevity research, with direct routes into our topic guides and the underlying literature.
Aging is a system
of connected processes.
The 2023 hallmarks framework describes twelve interconnected features of aging, including genomic instability, telomere attrition, epigenetic alterations, cellular senescence, and chronic inflammation. It offers a way to organize questions, rather than a single explanation or a ready-made treatment. López-Otín et al. (2023), Hallmarks of aging: An expanding universe ↗
LERI’s guides focus on selected areas where computational and biological expertise can meet. These are areas of interest for exchange and collaboration, not claims that LERI currently operates a clinical program in each field.
AI & data
What can AI really tell us about biological age?
A practical guide to aging clocks, model validation, and the gap between prediction and understanding.
Cellular biology
Senolytics: from an intriguing mechanism to meaningful evidence
Why researchers study senescent cells, and what it takes to translate experimental findings into clinical benefit.
Genetics
Telomeres, telomerase, and the challenge of translation
Looking beyond the “cellular clock” metaphor to the questions a credible longevity study must answer.
Genetics
Epigenetic reprogramming: promise, precision, and open questions
Understanding what influential experiments show—and why restoring one function is different from reversing aging everywhere.
Human research
Caloric restriction: what a human study can—and cannot—tell us
Using CALERIE to understand endpoints, biological-age measurements, and careful interpretation of human research.
Read with context
What kind of evidence
are you looking at?
Cells & mechanisms
Useful for testing a biological idea. Ask how the experimental system relates to the organism or tissue you ultimately care about.
Animal studies
Useful for examining function in an organism. Keep the species, disease model, intervention, and follow-up visible in the interpretation.
Human studies
Read the population, comparator, primary endpoint, and safety results. A biomarker finding and a clinical benefit answer different questions.
A global invitation
Bring your questions.
Find your next collaboration.
The questions behind the science
Life extension.
How far can research take us?
Explore longevity, immortality, and the ambition to stop or reverse aging—with clear definitions and links to the evidence.