Life ExtensionThe LERI reading room
Longer explanations of selected research topics, written to help specialists and curious readers find common ground.
7 guides
Longevity fundamentals / Research guide
What is life extension research, and how does it differ from immortality? Explore lifespan, healthspan and the questions driving longevity science.
Read the guide ↗Longevity fundamentals / Research guide
Explore the science behind stopping or reversing aging: cellular reprogramming, senolytics, biological-age measures and the evidence researchers need.
Read the guide ↗AI & data / Research guide
A practical guide to aging clocks, model validation, and the gap between prediction and understanding.
Read the guide ↗Cellular biology / Research guide
Why researchers study senescent cells, and what it takes to translate experimental findings into clinical benefit.
Read the guide ↗Genetics / Research guide
Looking beyond the “cellular clock” metaphor to the questions a credible longevity study must answer.
Read the guide ↗Genetics / Research guide
Understanding what influential experiments show—and why restoring one function is different from reversing aging everywhere.
Read the guide ↗Human research / Research guide
Using CALERIE to understand endpoints, biological-age measurements, and careful interpretation of human research.
Read the guide ↗No guides match that search. Try another term or choose all research areas.
These are introductory research guides, not original LERI research papers or a comprehensive review of the field. Published November 2, 2026. Each guide links to its selected sources.
Add your perspective
Have a paper worth discussing, a method worth explaining, or a collaboration worth proposing? Share an article that helps someone from another discipline understand your question.
See the contribution guide ↗The questions behind the science
Explore longevity, immortality, and the ambition to stop or reverse aging—with clear definitions and links to the evidence.