AI & data / Research guide
What can AI really tell us about biological age?
A practical guide to aging clocks, model validation, and the gap between prediction and understanding.
Read the guide ↗
Life ExtensionLife Extension Research Institute
Life extension research connects AI, medicine, and aging biology. LERI brings independent minds together to share findings and investigate a longer, healthier human future.
The idea behind LERI

What becomes possible when researchers stop working in isolation?
LERI is building a worldwide associate network to exchange research findings, discuss methods, and connect complementary expertise. We welcome independent researchers alongside those working in universities and other institutions.
Our focus is the science of aging—and the responsible use of AI to help investigate it. We want to turn curiosity into clear questions, useful articles, and conversations that lead to better research.
Discover our mission ↗Start exploring
AI & data / Research guide
A practical guide to aging clocks, model validation, and the gap between prediction and understanding.
Read the guide ↗Cellular biology / Research guide
Why researchers study senescent cells, and what it takes to translate experimental findings into clinical benefit.
Read the guide ↗Genetics / Research guide
Looking beyond the “cellular clock” metaphor to the questions a credible longevity study must answer.
Read the guide ↗At the intersection
New tools are most useful when they help answer a well-defined question. Explore how genetics, reprogramming, and AI meet—and why validation matters as much as an exciting result.
Read about reprogramming ↗A place to contribute
Contribute an article, compare approaches, or bring a question that needs another discipline’s perspective.
Explore accessible guides and follow the original papers. Keep evidence and interpretation in view.
Share a critical review, methods note, research explanation, or a focused collaboration proposal.
Introduce your expertise and research interests. Help build a network across borders and disciplines.
A global invitation
The questions behind the science
Explore longevity, immortality, and the ambition to stop or reverse aging—with clear definitions and links to the evidence.